Ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will enhance the amount or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has long been related to coadministration of ritonavir Hence, check clients who will be receiving concomitant medications which might be CYP450 ... https://k2-diablo-spice-spray20751.mybuzzblog.com/8818691/detailed-notes-on-k2-diablo-spice-spray